IL4 and rheumatoid arthritis: Our results reveal that baseline STAT6 phosphorylation level, as determined by whole blood phospho-specific flow cytometry, in monocytes upon IL-4 stimulation is positively correlated with good treatment response to synthetic DMARDs in patients with recent-onset untreated RA, and, that baseline STAT1 phosphorylation level in lymphocytes upon IFN-γ stimulation is positively correlated with good treatment response to biological drugs in patients with chronic RA.