The study adenovirus coated protein gene mutation junction constructs desmin disease animal model, by contrasting immunohistochemical results of desminopathy patient-related diseases and animal models of desminopathy disease, we found that desmin mutation and VDAC1, bax, bcl-2, HKII, ATF2 are closely related, it provided ideas for the study of other neurological protein aggregation diseases, also provides a new approach for drug development. This evidence concerns the gene ATF2 and Desminopathy.