KIF20A and pancreatic ductal adenocarcinoma: In addition, decreased levels of endogenous KIF20A in pancreatic ductal adenocarcinoma cells altered the subcellular localization of the DLG5 protein (a scaffolding molecule involved in cell-cell contact) from the cytoplasmic membranes to the cytoplasm, resulting in drastically attenuated pancreatic cancer cell growth [24].