CD44 and neoplasm: We report that overexpression of oncogene combination mRas/mp53/mPIK3CA in both cell types induces complete transformation, as assessed by increased anchorage independence and increased invasion/migration in-vitro, increased levels of CD44+/CD24low tumor-initiating population; and in-vivo tumors when orthotopically implanted into mammary glands of NOD/SCID gamma (NSG) mice.