Recurrent gene changes, such as mutations in PIK3CA, TP53, MAP3K1, RUNX1, gene amplification/over-expression of ErbB2, loss of tumor suppressor PTEN, and RB, and their association with different breast cancer subtypes, signifies an important gene alteration and subtype relationship [4, 5, 7]. The gene discussed is ERBB2; the disease is breast carcinoma.