Importantly, three of the dysregulated genes encode enzymes linked with human genetic disorders of glyoxylate detoxification (alanin-glyoxylate amino transferase [agxtb], glyoxylate reductase/hydroxypyruvate reductase [grhprb] and 4-hydroxy-2-oxoglutarate aldolase 1 [hoga1], which are involved in human primary hyperoxalurias type I-III, respectively [17]). Here, HOGA1 is linked to primary hyperoxaluria.