Notably, the mechanism described in this study is likely also relevant to human DN and other human kidney diseases, because MeCP2 expression has been reported to be increased in the kidneys of patients with chronic kidney disease, lupus nephritis, FSGS, IgA nephropathy as well as DN (https://www.nephroseq.org/resource/main.html). This evidence concerns the gene MECP2 and focal segmental glomerulosclerosis.