We hypothesized that MeCP2 phosphorylated by HIPK2 (p-MeCP2) may affect miRNA processing in diabetic kidney disease based on recent reports showing the role of p-MeCP2 in suppressing nuclear miRNA processing27 and that HIPK2 can phosphorylate MeCP2 at Ser 8033. Here, HIPK2 is linked to diabetic kidney disease.