However, in type 2 diabetes mellitus (T2DM), the body is not able to effectively utilize insulin to maintain normoglycemic level, and the hepatic glucose output is not in the ambit of control of insulin and leads to hyperglycemia, which is reflected by higher fasting blood glucose level (BGL).1, 2, 3 Clinical reports have shown that there is an association between testosterone levels and metabolic syndrome in men, and testosterone deficiency leads to T2DM. This evidence concerns the gene INS and metabolic syndrome.