Beneficial effects of GLP-1 were reported on modulation of ECM remodelling in mice myocardium showing that Exendin-4 may be able to protect from post-myocardial infarction associated interstitial fibrosis by limiting inflammation and reducing transforming growth factor β3 (TGFβ3) and collagen expression,7 however, the direct effects of GLP-1 on AT, especially in view of inflammation and ECM remodelling have not yet been examined. Here, GLP1R is linked to myocardial infarction.