OMAT and abdominal SCAT exhibit different patterns of gene expression,28 OMAT has higher lipolytic activity15 and has as part of visceral AT a clear link with the development of metabolic syndrome characteristics (including glucose intolerance, hyperinsulinemia and hypertriglyceridemia) and cardiovascular disease.15 We postulated that the difference between OMAT and SCAT response could have been due to a differential expression of GLP-1R. The gene discussed is GLP1R; the disease is hyperinsulinism.