APOE and obesity due to melanocortin 4 receptor deficiency: Elastin confers resilience, elasticity and deformability to many connective tissues including AT.3 Elastin was reported to be less abundant in AT from non-diabetic obese than lean subjects when assessed by immunohistology.23 Furthermore, mice with haplo-insufficiency of the elastin gene in a ApoE−/− background had impaired glucose metabolism and demonstrated adipocyte hypertrophy,24 supporting that elastin production is impaired in obesity and that it may have a role in glucose metabolism.