Sharpin (1–351) lacks the NZF (Npl4 zinc finger) domain and Sharpin (1–221) lacks both the NZF and UBL (ubiquitin-like) domains, which are both important for NF-κB activation.5 The NZF domain deletion decreased HCC invasion to the control cell level and deletions of both the NZF and UBL domains of Sharpin markedly decreased HCC invasion (Figure 2d), showing that these domains of Sharpin are critical for HCC invasion. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.