Aberrant regulation of NF-κB and the signaling pathways that control its activity often leads to inflammation, drug/radiation resistance and tumorigenic potential of cancer cells.12 As an AKT effector, NF-κB is critical to the acidosis-induced tumor initiation, progression and invasion.5 However, a question remains as to whether acidosis can still induce the cell signaling and impact different aspects of tumorigenesis in the highly active AKT background. The gene discussed is NFKB1; the disease is neoplasm.