In our study, catabolic genes, including MMP-3 and -9 and ADAMTS5, and the proinflammatory cytokines, including CCL-2 and-5 and CXCL1, were also inhibited by DHA treatment, suggesting the potential role of DHA in maintaining cellular homeostasis and treating osteoarthritis. The gene discussed is CXCL1; the disease is osteoarthritis.