AKT1 and early-onset autosomal dominant Alzheimer disease: The up regulated proteins are involved in the following pathways: malaria, nicotinate and nicotinamide metabolism, salmonella infection, ECM-receptor interaction, tight junction, phagosome, Alzheimer’s disease, focal adhesion, regulation of actin cytoskeleton, PI3K-Akt signaling pathway and metabolic pathways (Fig. 1).