The results of the K-M curve analyses revealed that use of the pN stages led to both underestimates (i.e., pN2, LNR ≤ median and pN1, CEA (−)) and overestimates in OS (i.e., pN0, CEA (+) and pN1, CEA (+)) of patients with CRC. The gene discussed is CEACAM5; the disease is colorectal carcinoma.