Furthermore, it is worthy to note that NOX4 strongly mediates apoptosis and senescence in HCC cells,43, 44 as well as regulates homocysteine metabolism, which impacts on hepatic glutathione levels.45 Altogether suggest that NOX4 could have liver-specific functions, and its role may differ from other tumours, where it induces migration and cell survival.41, 42, 46, 47. Here, NOX4 is linked to hepatocellular carcinoma.