Indeed, RhoA transcription is orchestrated by the Myc/Skp2/Miz1/p300 transcription complex.52 Interestingly, it has been described that upregulation of NOX4 in HCC cells is coincident with c-Myc downregulation,43 which would justify its capacity to inhibit Rho GTPases expression. Here, SKP2 is linked to hepatocellular carcinoma.