AGR2 and keratoconus: As shown in Figure 2f, loss of Agr2 resulted in a significant reduction (P<0.001) in both the number of pre-neoplastic lesions (2.23±1.01 vs 15.89±1.19) and their foci (1.15±0.49 vs 9.94±0.65) in KCA (n=13) compared to KC (n=18) mouse pancreata, respectively.