To further understand the mechanisms of how immune homeostasis and immune compounds are affected by Nrf2 deficiency, and how Nrf2 deficiency increases susceptibility to LN, we produced Nrf2−/−lpr/lpr mice with a C57BL/6 background (designated as B6.Nrf2−/−lpr/lpr) to observe the clinical development of LN. This evidence concerns the gene NFE2L2 and lobular neoplasia.