After these adjustments, serum sPLA2-IIa protein levels exhibited significant associations with ICAM-1 (r = 0.289, p = 0.014), VCAM-1 (r = 0.270, p = 0.032), E-selectin (r = 0.324, p = 0.007), and P-selectin (r = 0.248, p = 0.040) in MetS patients. This evidence concerns the gene ICAM1 and metabolic syndrome.