Remarkably, haematoxylin and eosin and immunofluorescence (IF) staining for Vimentin/E-Cadherin revealed that, in Ptenpc−/−; Trp53pc−/− mice treated with PF-03084014, tumour grade and percentage of invasive glands was significantly reduced when compared with Ptenpc−/−; Trp53pc−/− control mice (Fig. 3a). Here, CDH1 is linked to neoplasm.