VEGFA and chronic kidney disease: Similarly, in the study by Miyake et al., in the Japanese population, renal function tended to worsen during anti-VEGF treatment; however, no significant differences in the reduction in eGFR were detected according to the CKD-EPI (Chronic Kidney Disease-Epidemiology Collaboration) formula during sunitinib-, sorafenib- or axitinib-treatment [77].