TLR3 and neoplasm: In esophageal cancer TLR3, -4, -7, and -9 overexpression has been demonstrated in 70%, 72%, 67%, and 78% of patient tumors, respectively, and, as in breast cancer, poor prognosis was associated with elevated TLR3 expression on tumor cells, however, patients expressing increased TLR9 associated with fibroblasts exhibited improved survival [12,13,14].