Western blot analysis of pancreatic tissue showed no protein expression of TLR2, -4, and -9 in normal pancreatic tissue (NT) compared to increased expression in tissue of chronic pancreatitis (CP) and in particular in primary pancreatic cancer at all stages (UICC I, IIA, IIB, III, and IV) (Figure 1A). This evidence concerns the gene TLR2 and familial pancreatic carcinoma.