MIAPaCa-2 cells treated with the TLR ligands demonstrated comparably more pronounced pErk activation then BxPC-3 cancer cells (ODN: ROD = 357%, LTA: 295%, LPS: 135%, HMGB1: 296%, ODN + HMGB1: 242%, LTA + HMGB1: 329%, and LPS + HMGB1: 282%). The gene discussed is EIF2AK3; the disease is cancer.