PaCaDD135 cells expressed increased Bcl-xL in a range between the other two analyzed cancer cell lines (ODN ROD = 141%, LTA: 142%, LPS: 124%, HMGB1: 113%, ODN + HMGB1: 133%, and LPS + HMGB1: 110%) (Figure 8C, right). The gene discussed is HMGB1; the disease is cancer.