HMGB1 and neoplasm: Activation of TLR2 with LTA and LTA + HMGB1 resulted in significantly increased tumor cell proliferation in MIAPaCa-2 cells (120% and 123%, p < 0.05), BxPC-3 cells (117% and 132%, p < 0.0001) and PaCaDD135 cells (117% and 114%, n.s. and p < 0.005) compared to untreated cells (Figure 10A).