Interestingly, we have previously shown that non-enzymatic nitration of the basement membrane is a relevant model system to study BM pathology and can affect RPE dysfunction, such as altered VEGF secretion, phagocytic ability, and expression of complement regulatory proteins in a manner that mimics the effects of BM aging in AMD [50,51,52,53]. Here, VEGFA is linked to age-related macular degeneration.