This could give a strong rationale to not overuse active vitamin D analogues in the treatment of CKD-MBD in patients with renal failure; however, as has already been mentioned, there is some experimental data suggesting that Klotho restoration in the vasculature obtained by VDR activation with calcitriol led to the FGF23 mediated inhibition of calcification [63]. The gene discussed is KL; the disease is chronic kidney disease.