In disease models of obstructive hydrocephalus, focal cortical-freeze injury, brain tumor and intraparenchymal saline infusion, AQP4-deficient mice showed more severe hydrocephalus, markedly increased intracranial pressure, limited water elimination and poor neurological scoring when compared with their wild-type corresponding controls [29,30,31]. The gene discussed is AQP4; the disease is Hydrocephalus.