In line with the unfavorable prognosis of patients with p65high DLBCL, GEP analysis found that JUN and PTPRD (involved in cell cycle progression) were upregulated (1.43-fold and 1.31-fold respectively) whereas pro-apoptotic NOXA/PMAIP1 and BTG3 which negatively regulates proliferation and cell cycle progression were downregulated (1.62-fold and 1.45-fold, respectively) in p65high DLBCL compared with p65low DLBCL. The gene discussed is PMAIP1; the disease is diffuse large B-cell lymphoma.