Paradoxically, antiapoptotic BIRC6, MCM10 (involved in the initiation of eukaryotic genome replication), CARS (cysteinyl-tRNA synthetase) and PA2G4 (involved in growth regulation) were downregulated in p65high patients, and TENC1 (which inhibits AKT1 signaling) was upregulated in p65high DLBCL. The gene discussed is MCM10; the disease is diffuse large B-cell lymphoma.