Paradoxically, antiapoptotic BIRC6, MCM10 (involved in the initiation of eukaryotic genome replication), CARS (cysteinyl-tRNA synthetase) and PA2G4 (involved in growth regulation) were downregulated in p65high patients, and TENC1 (which inhibits AKT1 signaling) was upregulated in p65high DLBCL. This evidence concerns the gene AKT1 and diffuse large B-cell lymphoma.