MYD88 and diffuse large B-cell lymphoma: In comparison, in GCB-DLBCL but not in ABC-DLBCL, TNFRSF13C which encodes the receptor specific for BAFF (non-canonical activation), MYD88 which encodes an adapter protein essential for the Toll-like receptor (TLR) and interleukin-1 receptor signaling pathways, and MAP3K14/NIK which is involved in non-canonical activation of NF-κB were significantly upregulated in the p65high compared with p65low group (Fig. 3F-H).