In ABC-DLBCL, p65high GEP signatures were featured by proliferation and anti-apoptosis, whereas in GCB-DLBCL in which subgroup p65 hyperactivation showed significant adverse prognostic impact, p65high expression was accompanied with upregulation of some pro-apoptosis genes as well as many immune genes. This evidence concerns the gene RELA and diffuse large B-cell lymphoma.