These findings may suggested that although p65 subunit only manifested prognostic significance in certain DLBCL subsets due to the complexity of NF-κB dimers and activating mechanisms, in vitro experiments nonetheless demonstrated that NF-κB overexpressing DLBCL cells were addictive to NF-κB and vulnerable for NF-κB inhibitors. The gene discussed is RELA; the disease is diffuse large B-cell lymphoma.