Bruton tyrosine kinase gene BTK which plays an important role in BCR signaling activation (canonical activation), and TNFRSF13B which encodes the tumor necrosis factor receptor for APRIL and BAFF were significantly upregulated in p65high ABC-DLBCL but not in p65high GCB-DLBCL (Fig. 3D-E). This evidence concerns the gene BTK and diffuse large B-cell lymphoma.