NFKB1 and diffuse large B-cell lymphoma: BZ and BAY-11 inhibit NF-κB by different mechanisms, as we analyzed the cell lysates from BZ-treated and BAY-11-treated DLBCL-MS cells to a 20S proteasome proteolysis assay, and found proteasome activity was substantially inhibited (>50%) after 3 hours of BZ treatment, whereas BAY-11 treatment did not affect proteasome activity in a similar time points (Fig. 7B).