First, we examined whether specific inhibition of NF-κB was sufficient to block cell survival by over-expressing a super repressor mutant form of IκBα (pCMV-IκBαM) in a representative DLBCL cell line, MS, that has been previously shown to have constitutive NF-κB activation [44]. The gene discussed is NFKBIA; the disease is diffuse large B-cell lymphoma.