PMAIP1 and diffuse large B-cell lymphoma: In contrast, in p65high ABC-DLBCL, antiapoptotic BIRC5 and BCL2L2 were significantly upregulated whereas pro-apoptotic NOXA/PMAIP1 was significantly downregulated (Fig. 3B-C), in addition to the proliferative signatures (such as upregulation of genes involved in replication, transcription, translation, and metabolism) in ABC-DLBCL (Table 3).