UHRF1 and diffuse large B-cell lymphoma: In the GEP comparison in overall DLBCL, a few immune-related genes were also found up- or down-regulated in p65high DLBCL compared with p65low DLBCL, including upregulation of LCP2 (lymphocyte cytosolic protein 2, involved in T cell receptor signaling, 1.27-fold) and TEK (anti-inflammatory, 1.21-fold), and downregulation of UHRF1 (an epigenetic regulator promoting proliferation of immunosuppressive Treg cell, 1.48-fold down-regulation) [43] in p65high DLBCL (Table 3).