Except for p52, downregulation of p65, c-Rel, and RelB protein expression with individual shRNAs inhibited DLBCL cell growth (thymidine incorporation assay), and inhibition of p65 was most effective (Fig. 5D), particularly in cell lines with mutated p53 (MS, LP and HB). The gene discussed is TP53; the disease is diffuse large B-cell lymphoma.