Deletion at mid-gestation leads to similar phenotype as Tie2 knockout. Deletion at E12.5 results in subcutaneous oedema and abnormal patterning of dermal lymphatic vessels. Deletion at E16.5 shows no obvious phenotype until 21–28 days when high intraocular pressure, buphthalmos and features of glaucoma start to develop due to defects in Schlemm's canal and lymphatic capillaries in corneal limbus. Here, TEK is linked to congenital glaucoma.