Double Ang1/Ang2 gene deletion and embryonic Tie2 deletion at E16.5 led to defective development of the SC and lymphatic capillaries in corneal limbus, resulting in clinical features of glaucoma (high IOP, buphthalmos, retinal ganglion degeneration and vision loss) 21–28 days after birth [52]. This evidence concerns the gene TEK and glaucoma.