Genetic risk ratios for CHD per 65% lower Lp-PLA2 activity (i.e. the reduction achievable with darapladib treatment) were: 0.95 (0.88–1.03) with Val279Phe in East Asians; and 0.92 (0.74–1.16) with carriage of any one of the four rare variants studied in Europeans and South Asians; and 1.01 (0.68–1.51) with Val379Ala (Table 2). This evidence concerns the gene PLA2G7 and coronary artery disorder.