PLA2G7 and coronary artery disorder: In over 260,000 participants of European, South Asian, or East Asian ancestries, we studied five functional variants in PLA2G7. We compared effects of Lp-PLA2-lowering alleles on soluble Lp-PLA2 activity, conventional cardiovascular risk factors and CHD risk with corresponding effects of darapladib, using results from randomized trials.