PLA2G7 and coronary artery disorder: In people of European or South Asian ancestry without CHD, the frequency of alleles in PLA2G7 that lower Lp-PLA2 activity was 0.005% at c.109 + 2T > C, 0.04% at Arg82His, 0.04% at Val279Phe and 0.025% at Gln287Ter (i.e. in aggregate, 0.2% of the European or South Asian participants in the current study carried one of these loss-of-function alleles, although no one carried more than one of these variants), and about 80% at Val379Ala.