PLA2G7 and coronary artery disorder: It could be that cardioprotective benefits of Lp-PLA2 inhibition were obscured by pleiotropic effects of PLA2G7 variants; for example, 279Phe is known to produce a misfolded version of Lp-PLA2 not secreted by cells, prompting suggestions that its carriage could produce ‘off-target’ effects such as increased cell death.33,34 However, because we found null associations between four other functional alleles in PLA2G7 and CHD, each of which operates via a different molecular mechanism, it argues against this explanation.