Giving hope for translating intrinsic axon growth regulators into treatment in CNS injury, introduction of AAV2-Id2 at the injured EH dramatically enhanced axon regrowth and infection with AAV2-Id2 with active Akt noticeably enhancing axon regrowth, whereas AAV2-Id2 with Akt inhibitor failed to promote axon regeneration. Here, ID2 is linked to infection.