However, these FAD neurons that were not able to fully recapitulate did not show robust extracellular Aβ plaques, Aβ-induced p-tau pathology, NFT pathologies such as aggregated with paired helical filaments (PHFs); neither did they display any signs of neurodegeneration, as predicted in the amyloid hypothesis and observed in AD patients. Here, MAPT is linked to Alzheimer disease.