A number of “nontraditional” risk factors for PAD have also been recognized including race and ethnicity, elevated inflammatory markers such as C-reactive protein, fibrinogen, leukocytes and interleukin-6, genetics, hypercoagulable states of altered blood levels of D-dimer, homocysteine, lipoprotein, and an abnormal waist-to-hip ratio [8]. This evidence concerns the gene CRP and peripheral arterial disease.