G6PD and hyperinsulinemic hypoglycemia, familial, 4: The prevalence and extent of g6pd deficiency is a major concern for malaria eradication programmes, where they plan to use PQ as a gametocidal agent as although a single low dose of PQ has been suggested to be well tolerated in G6PD deficient malaria patients, PQ has been found at certain concentrations and in certain instances to cause RBC lysis in g6pd deficient individuals [48–50].