This seems pleasing and would improve prognosis in equine disease compared to human asthma, but further studies should be performed on the role of MMP-8, as airway remodeling is definitely a long-term effect of equine RAO leading to irreversible exercise insufficiency, but fibrosis formation might not be a direct consequence of TIMP overexpression in the horse. This evidence concerns the gene TIMP1 and glycogen storage disease VI.