In this study, to investigate Cav-1 expression in IPF after pirfenidone, prednisone and acetylcysteine treatments, and compare the effects of pirfenidone with other two agents (acetylcysteine and prednisone) on IPF, rat IPF model was established by endotracheal injection of bleomycin A5. This evidence concerns the gene CAV1 and idiopathic pulmonary fibrosis.