Taken together, in the lung of IPF treated by pirfenidone, acetylcysteine and prednisone, increased expression of Cav-1 may contribute to the remission of airsacculitis and fibrosis through its negative correlations with TGF-β1, TNF-α and PDGF. The gene discussed is TGFB1; the disease is idiopathic interstitial pneumonia.