In the present study, rat IPF model was established by endotracheal injection of bleomycin A5 in order to investigate the role of Cav-1 expression in IPF after pirfenidone, acetylcysteine and prednisone treatments, and compare the effects of pirfenidone with acetylcysteine and prednisone on IPF. Here, CAV1 is linked to idiopathic pulmonary fibrosis.