In the present study, rat IPF model was established by endotracheal injection of bleomycin A5 in order to investigate the role of Cav-1 expression in IPF after pirfenidone, acetylcysteine and prednisone treatments, and compare the effects of pirfenidone with acetylcysteine and prednisone on IPF. The gene discussed is CAV1; the disease is idiopathic interstitial pneumonia.