1997; Katzen et al. 1998; Yankner et al. 2008). Therefore, aging-related genes may be an effective therapeutic target for PD. Our observations of prolonged lifespan in MESA-treated worms led us to postulate the involvement of aging-related genes in MESA’s neuroprotective potential. Previously, dozens of genes that blocks α-synuclein inclusion were identified in C. elegans and some of them also participated in longevity regulation (van Ham et al. 2008). This evidence concerns the gene SNCA and Parkinson disease.