For example, PTEN negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and acts as a tumor suppressor by negatively regulating Akt/PKB signalling pathway[10].The PTEN pseudogene (PTENp1) is a processed pseudogene, which shows high sequence similarity with PTEN in human. Here, AKT1 is linked to neoplasm.