AQP4 and myeloid sarcoma: For MS, Saidha et al reported a thinning of the inner nuclear layer (INL) and ONL in eyes without peripapillary RNFL thinning.[21] They suggested that the morphological changes were due to a primary retinal pathology.[21] For NMOSD, Syc et al[17] suggested that the ONL thinning resulted from an inflammation of the Müller cells secondary to a direct attack on Müller cells by anti-AQP4 antibody.