CAMK2B and drug dependence: Neurotransmitter signaling plays a key role in drug dependence [3,15]; CAMK2B (calcium/calmodulin dependent protein kinase II beta) was shown to be a hub molecule in pathways relevant to drug addiction [16], whereas long term potentiation could modulate heroin relapse through the glutamate receptor NR2B (NMDA2b-containing receptor) [17].