GH1 and Hepatitis: With GH treatment, increased Hnf6 and reduced BDL hepatic fibrosis are associated with diminished Tgfb2r gene and protein [8], suggesting that Hnf6 negatively regulates Tgfb2r. Furthermore, Tgfb2r signaling is increased in global Hnf6 null mice embryonic liver [47], while our ChIP-on ChIP data show over-amplified Tgfb2r promoter in KO relative to WT liver (data not shown).