This is paralleled by attenuated cholestasis with lower serum alkaline phosphatase [8] (Fig 2A), diminished α-smooth muscle actin (α-Sma) marker for fibrosis (Fig 2B and 2C) and profibrotic genes Ctgf, Tgfb2R (Fig 2D and 2E) in GH-treated BDL WT liver relative to PBS BDL liver. Here, SMN1 is linked to cholestasis.