Our analysis narrowed down the CRC recurrence signature to five genes (S100A2, VIP, HOXC6, DACT1, and KIF26B) whose expression was associated with poor OS (log-rank test P-value: 1.19 × 10−4) and DFS (log-rank test P-value: 0.002), which was further confirmed in a multivariate analysis. The gene discussed is HOXC6; the disease is colorectal carcinoma.