MYC and hematologic disorder: While efforts to target MYC have been largely unsuccessful, the novel triazolothienodiazepine BET inhibitor OTX015 (MK-8628) [13] has shown potent preclinical antitumor activity in hematologic malignancies [14, 15] as well as in several solid tumors [16–18], in association with down-regulated MYC expression.