MYC and cancer: Taking into account the fact that triple-negative breast tumors are considered to be driven by c-MYC [4] and that BET inhibitors OTX015 and JQ1 have been reported to induce c-MYC down-regulation in several cancer types [14, 15, 17, 30, 31], we hypothesized that OTX015 would exert antitumor effects in TNBC cell models by down-regulating c-MYC expression.