AKT1 and neoplasm: It is well known that targeting specific signaling pathways crucial for tumor growth, such as PI3K/AKT/mTOR, tyrosine kinase receptors and MAPK/ERK, elicits adaptive kinome and transcriptome responses which trigger a global reorganization of cell signaling machinery in order to up-regulate alternative kinase signaling networks or reactivate the targeted pathway to overcome the repressive treatment [36].