Of note, LY6D, ST3GAL4, ASS1, PTP4A3 (also named PRL-3), UBE2C (also named UBCH10), and E2F3 are novel oncogenes and biomarkers whose overexpression are related to metastases, migration, or proliferation of NSCLC and other cancers [27–39]. The gene discussed is E2F3; the disease is cancer.