The results revealed that preoperative Fib (P < 0.001), Child-Pugh stage (P = 0.037), AFP (P < 0.001), size of largest tumor (P < 0.001), tumor number (P < 0.001), macro-vascular invasion (P < 0.001), micro-vascular invasion (P < 0.001) and NLR (P = 0.013) were responsible for the DFS. The gene discussed is FBL; the disease is neoplasm.