The associations of preoperative Fib and NLR with clinicopathologic variables of patients with HCC were investigated, and the data showed that preoperative Fib was correlated with Child-pugh stage (P < 0.001), alpha-fetoprotein (AFP) (P = 0.005), size of largest tumor (P < 0.001), macro-vascular invasion (P = 0.003), and micro-vascular invasion (P < 0.001). The gene discussed is AFP; the disease is hepatocellular carcinoma.