For instance, in B-cell lymphomas approximately 39 and 41% of the diffuse large B-cell and follicular lymphoma cases, respectively display genomic deletions, somatic mutations, or both that remove or inactivate the HAT coding domain of the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) binding protein (CREBBP) and adenovirus early region 1A (E1A) binding protein P300 (EP300). The gene discussed is EP300; the disease is B-cell non-Hodgkin lymphoma.