Infection with wild-type H. pylori enhanced phosphorylation at Tyr972 in CagA compared with an infection with the vacA mutant strain (Fig. 4B), suggesting that VacA might be specifically associated with phosphorylation at Tyr972 and its corresponding sites within EPIYA-C motifs of CagA in H. pylori infection. The gene discussed is S100A8; the disease is infection.