Strikingly, mice with active HH signaling in the stroma (SmoM2;PB-MYC) showed a significant decrease in tumor grade compared with PB-MYC littermates (Fig. 6G) (Mann–Whitney U test: U=53, n1=n2=14, P=0.0096 two-tailed). The gene discussed is MYC; the disease is neoplasm.