Analysis of the TCGA dataset (n=330) of primary PCa samples (Abeshouse et al., 2015) and the MSKCC Prostate Oncogenome Project (n=29 normal, 131 primary tumors, and 19 metastases) (Taylor et al., 2010) revealed that the overall expression of IHH, but not SHH or DHH is significantly increased in tumor samples compared with normal prostate samples (Fig. S13A). This evidence concerns the gene SHH and posterior cortical atrophy.