MYC and neoplasm: Although PB-MYC tumors have a prominent reduction of SMCs, the proportion of all cells (epithelial+stromal) that were stromal (EpCAM–) was significantly increased in both SmoM2;PB-MYC (P<0.0001) and PB-MYC (P<0.0001) prostates compared with non-tumor controls, and was significantly higher in SmoM2;PB-MYC than PB-MYC tumors (P=0.0004) (Fig. 7G).