Analysis of TCGA, the largest RNA-seq dataset of primary PCa samples (Abeshouse et al., 2015), revealed a decrease in ACTA2 and CNN1 but not VIM expression in more advanced tumors (higher Gleason score), suggesting the proportion of SMCs in human tumors, or at least the expression levels of the cell type-specific genes are decreased. The gene discussed is ACTA2; the disease is posterior cortical atrophy.