Interestingly, whereas we detected little expression of Ihh or Dhh in the epithelium of normal prostates (Fig. 5G,G′,J,J′), Ihh was abundant in PB-MYC (Fig. 5H,H′; Fig. S11H,H′) and somewhat increased in TRAMP (Fig. 5I,I′; Fig. S11I,I′) tumor epithelium, and Dhh was detected in the tumor epithelium of both PB-MYC and TRAMP models, especially in TRAMP mPIN lesions (Fig. 5K,K′,L,L′; Fig. S11 K,K′,L,L′). This evidence concerns the gene DHH and neoplasm.