F-actin can relay its effect on YAP through several mechanisms such as G-protein-coupled receptors (GPCRs), which are known to combine the actin cytoskeleton with several signalling pathways (reviewed in Regue et al., 2013), or IQGAP1, a scaffold protein known to regulate the F-actin and microtubule network and shown to play a pivotal role in a bile acid-induced liver cancer through YAP (Anakk et al., 2013). The gene discussed is IQGAP1; the disease is liver cancer.