We chose the eight most differentially expressed genes (yap, ccnd1, ctgfa, iqgap1, tgfb1a, tgfbr2, amot, itgb2) and tested this signature on different tumour types and heterotopia that showed overexpression of all eight genes in tumours of the IVth ventricle and of six genes in telencephalic tumours, but no overexpression in heterotopia (Fig. 5B-D). The gene discussed is IQGAP1; the disease is neoplasm.