ZIC1 and neoplasm: By contrast, somatic co-expression of UAS:GFP-HRASV12 and UAS:YAPS5A (zic:RAS,YAPsomatic; Fig. 6A) promoted tumour development earlier than in zic:RASsomatic (2 weeks, data not shown), and increased proliferation at 3 dpf and 14 dpf (Fig. 6B,C) compared with zic:RASsomatic larvae.