We used different UAS-driven oncogenes, some activating the EGFR/RAS/ERK/AKT pathway, already reported to generate neoplasia in the zebrafish brain [GFP-KRASV12 (Ju et al., 2015), AKT (Jung et al., 2013)], others known to be oncogenic in human brain [GFP-EGFRtranscript variant III (vIII) (Liu et al., 2005), also represented by Xmrk, the oncogenic version of the EGFR in Xiphoporus, and BRAFE600 (Penman et al., 2015)] (see Table S1 for list and full names of constructs). The gene discussed is AKT1; the disease is neoplasm.