To generate a brain tumour model, we used the Gal4-UAS system to induce expression of different oncogenes under the UAS promoter in the driver line Et(zic4:GAL4TA4,UAS:mCherry)hmz5 (Distel et al., 2009), henceforth referred to as zic:Gal4. The gene discussed is ZIC1; the disease is brain neoplasm.