Unsupervised hierarchical clustering (Fig. 5E) demonstrates highly significant segregation of GBMs and LGGs (P<10–45, odds ratio=28, Fisher exact test) supporting that YAP activation is a hallmark of malignant brain cancer and suggesting that this eight-gene signature might provide sufficient information to distinguish high-grade from low-grade gliomas. The gene discussed is YAP1; the disease is glioma.