73, 83, 96, 97, 110 CX3CR1+ mononuclear phagocytes are a dominant source of IL‐23 during infection, which stimulates optimal ILC3 IL‐22 production.111 Conversely, ILC3 cytokine production is negatively regulated by epithelially derived cytokines such as thymic stromal lymphopoietin and IL‐25, which act to suppress IL‐22 production.112, 113 Therefore, signals from multiple intestinal resident cells combine to fine‐tune IL‐22 production by ILC3. This evidence concerns the gene IL22 and infection.