This is of relevance here as inhibition of these kinases has also been reported to affect super-enhancer-associated gene expression in T cell acute lymphoblastic leukaemia, B cell chronic lymphocytic leukaemia, MYCN-driven tumours, small cell lung cancer and triple negative breast cancer models where anti-tumour activity is observed (Kwiatkowski et al., 2014; Wang et al., 2015; Zhang et al., 2016; Christensen et al., 2014; Chipumuro et al., 2014). The gene discussed is MYCN; the disease is T-cell acute lymphoblastic leukemia.