CDK8 and cancer: The pleiotropic nature of CDK8/19 function, influencing the activity of multiple specific transcription factors and also super-enhancers, may make identification of biomarkers for particular cancer cell types that are especially sensitive to CDK8/19 inhibitors challenging; despite this both series of compounds did show greater potency in a systemic or subcutaneous model of human AML, similar to that reported for the natural product inhibitor of CDK8/19, cortistatin A (Pelish et al., 2015).