Cell-associated PRDX6 thus might participate in redox imbalance in AAA tissue through protective antioxidant functions or deleterious neutrophil-dependent NADPH activation; however, in a highly oxidative environment such as AAA, PRDX6 may lose its antioxidant activities through oxidative modification by lipid hydroperoxides41. This evidence concerns the gene PRDX6 and triple-A syndrome.