Chromatin remodeling proteins, including two members of the same SNF2-ATPase chromatin family as SRCAP, Lymphoid Specific Helicase (HELLS) and X-linked alpha thalassemia/mental retardation (ATRX), have also been shown to impact methylation status20, 21, 22, 23. The gene discussed is HELLS; the disease is alpha thalassemia-X-linked intellectual disability syndrome.