Accordingly, we found that the majority of down-regulated genes associated with oxidative phosphorylation in cFoxa1NtsCre vs wtFoxa1NtsCre neurons was also down-regulated in human caudate samples of HD compared to control caudate tissues, further suggesting a degenerate state of Foxa1-deficient STN neurons (Table S3)34. Here, FOXA1 is linked to Huntington disease.